Eosinophilic COPD: a Separate Disease Phenotype Warranting Specific Treatment
نویسنده
چکیده
منابع مشابه
Eosinophilic airway inflammation in COPD
Chronic obstructive pulmonary disease is a common condition and a major cause of mortality. COPD is characterized by irreversible airflow obstruction. The physiological abnormalities observed in COPD are due to a combination of emphysema and obliteration of the small airways in association with airway inflammation. The predominant cells involved in this inflammatory response are CD8+ lymphocyte...
متن کاملEosinophilic inflammation in COPD: prevalence and clinical characteristics.
Eosinophilic inflammation is thought to be a characteristic feature of asthma rather than COPD. However, studies have shown that a subset of COPD patients with eosinophilic airway inflammation exists, even after the careful exclusion of patients with any features of asthma, such as b-agonist reversibility, bronchial hyperresponsiveness, atopy or a childhood history of asthma [1–4]. Interestingl...
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BACKGROUND The role of exhaled H2S as a marker of airway inflammation and its relationship with COPD severity remain to be determined. METHODS Airway inflammation was classified in 77 COPD subjects based on the presence of inflammatory cells in induced sputum. We investigated the association between disease phenotype and exhaled H2S, lung function, and plasma levels of several inflammatory fa...
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Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by similar mechanisms: airway inflammation, airway obstruction, and airway hyperresponsiveness. However, the distinction between the two obstructive diseases is not always clear. Multiple epidemiological studies demonstrate that in elderly people with o...
متن کاملInterleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs
PURPOSE OF REVIEW Human eosinophils were first identified and named by Paul Ehrlich in 1879 on the basis of the cell's granular uptake of eosin. Although eosinophils represent approximately 1% of peripheral blood leukocytes, they have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophils and their mediators are critical effectors to asthma and eosinophilic gran...
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عنوان ژورنال:
دوره 16 شماره
صفحات -
تاریخ انتشار 2017